LIPID PEROXIDATION AND OXIDATIVE STRESS ELISA
Oxidatively modified lipoproteins (oxLDLs) play an important role in the progression of atherosclerosis and coronary artery disease. Accumulation of oxLDL in macrophages and smooth muscle cells causes foam cell formation, an initial step in the disease. Low-density lipoprotein (LDL), the main carrier of plasma cholesterol, consists of a hydrophobic core and a surface monolayer of polar lipids and Apolipoprotein-B (ApoB). Oxidative stress and the consequent formation of free radicals lead to the peroxidation of ApoB.
oLAB ELISA (BI-20032) for Determination of Autoantibodies against Oxidized LDL
An overview on the clinical applications of oLAB has been published.
OxyStat Assay (BI-5007) Determination of Peroxides in biological fluids
The determination of the oxidative status / oxidative stress is essential in today’s medical research and diagnostics. Methods used so far were either expensive (HPLC), or detected only degradation products of polyunsaturated fatty acids, like TBARS (thiobarbituric acid reactive substances).
The Biomedica OxyStat assay measures the total peroxide concentration of a sample, utilizing a quick and simple assay procedure. Results show a direct correlation between free radicals and circulating biological peroxides and thus allow the characterization of the oxidative status in biological samples.
MDA-oxLDL ELISA (BI-20022) for Determination of Oxidized LDL
The Biomedica MDAoxLDL ELISA specifically detects MDA-modified ApoB in human serum and citrate-plasma.