Oxidative Stress

oxidative stress MDA SOD

Oxidative stress describes the steady state level of oxidative damage in a cell, tissue, or organ, caused by the reactive oxygen species (ROS). This damage can have a widespread effect on an entire organism, or on just a single molecule. It is caused by an imbalance between the production of reactive oxygen and a biological system’s ability to readily detoxify the reactive intermediates or easily repair the resulting damage. All forms of life maintain a reducing environment within their cells through a constant input of metabolic energy which is preserved by enzymes. Disturbances in this normal redox state can cause toxic effects through the production of cell damaging peroxides and free radicals.

Research on human oxidative stress has led to links to many diseases such as atherosclerosis, Parkinson’s disease and Alzheimer’s disease and it may also be important in ageing. At the same time, reactive oxygen species can also be beneficial, as they are used by the immune system as a way to attack and kill pathogens.

About Reactive Oxygen Species (ROS)

Production of reactive oxygen species (ROS) like superoxide (O2·), hydrogen peroxide (H2O2), and hydroxyl radicals (•OH) is a normal part of life. Moderate concentrations are involved in a number of signaling pathways, synthesis of cellular structures, and host defense against pathogens. However, excessive or unchecked ROS production can cause cellular damage and has been implicated in a variety of pathologic and age-related conditions.

Understanding the role ROS play in health and disease is a common goal of many biomedical researchers. Arbor Assays’ oxidative stress kits can help answer your most challenging questions about oxidative stress mechanisms.

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About Arbor Assays

The founders and top scientists from Arbor Assays have been researching and developing high quality assay kits since 1982. Arbor Assays grew up making FDA-regulated in vitro diagnostic products for human disease detection. When they started to make products for the life sciences market in 1991 they realised that sensitivity, speed, convenience, quality and service were not associated with these products. They changed that for you.

On January 1, 2017, Arbor Assays became the world’s first Employee-Owned life sciences company by way of a perpetual employee benefit trust (EBT). As an EBT, the board of directors ensures that the company remains an independent entity for the benefit of customers and employees. For the customer, employee ownership means that the company can be counted on to continuously experiment, innovate, and provide high-quality products. For employees, ownership means increased job security and career satisfaction without the fear that Arbor Assays will be sold out to a larger development company.

MBIOSCIENCE is the authorised distributor for Arbor Assays in Malaysia.