PROGSTAGLANDIN (PGE2 ) PIVOTAL INFLAMMATION MARKERS
Scientific Relevance of Prostaglandin (PGE2)
Eicosanoid signal transduction pathways are highly conserved and are involved in a number of physiological processes.
Prostaglandins are synthesized from arachidonic acid by cyclooxygenase (COX)‑1 or ‑2, which convert the acid into PGH2. This is further processed by cytosolic or microsomal prostaglandin synthases to become PGE2 or one of several other prostanoids. Prostacyclin is the major cyclooxygenase product in blood vessel walls and it is present in inflammatory
fluids in similar concentrations to PGE2. Prostacyclin is a potent vasodilator and is more potent than PGE2 in producing hyperalgesia.