Prostaglandin (PGE2) Assay

PGE2 arbor assay prostaglandin


PGE2 is produced by a wide variety of tissues and in several pathological conditions, including inflammation, arthritis, fever, tissue injury, endometriosis, and a variety of cancers. Other biological actions of PGE2 include vasodilation, modulation of sleep/wake cycles, and facilitation of human immunodeficiency virus replication. It elevates cAMP levels, stimulates bone resorption, and has thermoregulatory effects. It has been shown to be a regulator of sodium excretion and renal hemodynamics.

Scientific Relevance of Prostaglandin (PGE2)

Eicosanoid signal transduction pathways are highly conserved and are involved in a number of physiological processes.

Prostaglandins are synthesized from arachidonic acid by cyclooxygenase (COX)‑1 or ‑2, which convert the acid into PGH2. This is further processed by cytosolic or microsomal prostaglandin synthases to become PGE2 or one of several other prostanoids. Prostacyclin is the major cyclooxygenase product in blood vessel walls and it is present in inflammatory
fluids in similar concentrations to PGE2. Prostacyclin is a potent vasodilator and is more potent than PGE2 in producing hyperalgesia.

Progtaglandin PGE2 pathway
PGE2 ELISA Kit Arbor Assay
PGE2 Myassays

PGE2 Multi-Format ELISA Kit (K051) from Arbor Assays

The DetectX® Prostaglandin E2 (PGE2) Multi-Format ELISA Kit is designed to quantitatively measure PGE2 present in serum, plasma, urine, tissues, saliva and culture media samples. This one ELISA kit allows all samples to be measured with just one kit.  The monoclonal antibody has super-fast kinetics and shows the same binding characteristics at 2 or 16 hour incubation. The kit allows samples as low as 2 pg/mL to be measured in less than 3 hours. It exhibits excellent cross reactivity and low sample requirements.